Publications

Major publications, books and reviews in the field of Proteincage Engineering

Publications

Publications

Category
Year of Publication

Showing 48 publications

2025

Gopal, M., Pham, V.M., Vadanan, V.S., Dang, T.T. and Lim, S., 2025. Curcumin-loaded bacterial cellulose films suppress in vitro melanogenesis in human epidermal melanocytes. Cellulose, 32, pp.1133–1148.

Design & Engineering

2024

Vadanan, V.S., Pasula, R.R., Joshi, N. and Lim, S., 2024. Bioengineering approach for the design of magnetic bacterial cellulose membranes. Communications Materials, 5, p.242.

Design & Engineering

2023

Ravishankar, S., Nedumaran, A.M., Gautam, A., Ng, K.W., Czarny, B. and Lim, S., 2023. Protein nanoparticle cellular fate and responses in murine macrophages. NPG Asia Materials, 15(1), pp.1–16.

Health & Medicine

Singh, J., Steele, T.W.J. and Lim, S., 2023. Bacterial cellulose adhesive patches designed for soft mucosal interfaces. Biomaterials Advances, 144, p.213174.

Design & Engineering

2022

Gupta, N.K., Okamoto, N., Karuppannan, S.K., Pasula, R.R., Ziyu, Z., Qi, D.C., Lim, S., Nakamura, M. and Nijhuis, C.A., 2022. The role of structural order in the mechanism of charge transport across tunnel junctions with various iron-storing proteins. Small, 18(42), p.2203338.

Electronics

Gupta, N.K., Karuppannan, S.K., Pasula, R.R., Vilan, A., Martin, J., Xu, W., May, E.M., Pike, A.R., Astier, H.P.A.G., Salim, T., Lim, S. and Nijhuis, C.A., 2022. Temperature-dependent coherent tunneling across graphene–ferritin biomolecular junctions. ACS Applied Materials & Interfaces, 14(39), pp.44665–44675.

Electronics

Kumar, K.S., Martin, J., Xu, W., Pasula, R.R., Lim, S. and Nijhuis, C.A., 2022. Biomolecular control over local gating in bilayer graphene induced by ferritin. iScience, 25(4), p.104128.

Electronics

Vadanan, V.S. and Lim, S., 2022. Development of conductive bacterial cellulose foams using acoustic cavitation. Cellulose, 29, pp.1–14.

Design & Engineering

Vadanan, V.S., Basu, A. and Lim, S., 2022. Bacterial cellulose production, functionalization, and development of hybrid materials using synthetic biology. Polymer Journal, 54(4), pp.481–492.

Design & Engineering

2021

Sun, R. and Lim, S., 2021. Protein cages as building blocks for superstructures. Engineering Biology.

Self-Assembly

Kumar, A., Nandwana, V., Ryoo, S.R., Ravishankar, S., Sharma, B., Pervushin, K., Dravid, V.P. and Lim, S., 2021. Magnetoferritin enhances T2 contrast in magnetic resonance imaging of macrophages. Materials Science and Engineering: C, 128, p.112282.

Health & Medicine

Kaku, T.S. and Lim, S., 2021. Protein nanoparticles in molecular, cellular, and tissue imaging. WIREs: Nanomedicine and Nanobiotechnology, p.e1714.

Health & Medicine

Bhaskar, S., Thng, S. and Lim, S., 2021. Engineered protein nanocages for targeted and enhanced dermal melanocyte cellular uptake. Advanced NanoBiomed Research, 1(7), p.2000115.

Health & Medicine

Kumar, K.S., Pasula, R.R., Lim, S. and Nijhuis, C.A., 2021. Room-temperature tunnel magnetoresistance across biomolecular tunnel junctions based on ferritin. Journal of Physics: Materials, 4(3), p.035003.

Electronics

Gupta, N.K., Pasula, R.R., Karuppannan, S.K., Lim, S. and Nijhuis, C.A., 2021. Switching of the mechanism of charge transport induced by phase transitions in tunnel junctions with large biomolecular cages. Journal of Materials Chemistry C, 9, p.10768.

Electronics

Lim, S. and Salentinig, S., 2021. Protein nanocage-stabilized Pickering emulsions. Current Opinion in Colloid & Interface Science, 56, p.101485.

Emulsion

2020

Nasrollahi, F., Sana, B., Paramelle, D., Ahadian, S., Khademhosseini, A. and Lim, S., 2020. Incorporation of graphene quantum dots, iron, and doxorubicin in/on ferritin nanocages for bimodal imaging and drug delivery. Advanced Therapeutics, 3(4), p.1900183.

Health & Medicine

Pasula, R.R., Kuniyil, A. and Lim, S., 2020. Molecular entrapment in thermophilic ferritin for nanoformulation in photodynamic therapy. Advanced Therapeutics, 3(4), p.1900172.

Health & Medicine

Sarker, M., Lee, H., Gonçalves, R.A., Lam, Y.M., Su, H. and Lim, S., 2020. Supramolecular protein assembly retains its structural integrity at liquid–liquid interface. Advanced Materials Interfaces, 7(7), p.1901674.

Emulsion

Mukhopadhyay, S., Karuppannan, S.K., Pasula, R.R., Lim, S., Nijhuis, C.A., Vilan, A. and Cahen, D., 2020. Solid-state protein junctions: cross-laboratory study shows preservation of mechanism at varying electronic coupling. iScience, 23(5), p.101099.

Electronics

Pham, T.T., Vadanan, V.S. and Lim, S., 2020. Enhanced rheological properties and conductivity of bacterial cellulose hydrogels and aerogels through complexation with metal ions and PEDOT/PSS. Cellulose, 27(14), pp.8075–8086.

Design & Engineering

2019

Sana, B., Krishnan, S., Shrivastava, A., Agrawal, R., Ghosh, S. and Lim, S., 2019. Targeted delivery of doxorubicin using humic acid-modified ferritin nanocages. ACS Biomaterials Science & Engineering, 5(5), pp.2359–2367.

Health & Medicine

Sarker, M., Sana, B. and Lim, S., 2019. Protein nanocages as templates for hierarchical self-assembly. Biomacromolecules, 20(6), pp.2149–2158.

Health & Medicine

Kumar, K.S., Karuppannan, S.K., Pasula, R.R., Lim, S. and Nijhuis, C.A., 2019. Ferritin-based biomolecular tunnel junctions operating in the clean transport regime. Advanced Electronic Materials, 5(11), p.1900504.

Electronics

2018

Bhaskar, S. and Lim, S., 2018. In vitro evaluation of the cellular uptake of engineered protein nanocages. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(2), pp.819–827.

Health & Medicine

Sana, B., Shrivastava, A. and Lim, S., 2018. Development of humic acid-ferritin hybrid nanoparticles for drug delivery applications. Bioengineering & Translational Medicine, 3(1), pp.46–54.

Health & Medicine

2017

Sarker, M. and Lim, S., 2017. Engineered protein nanocages for hierarchical assembly. Journal of Materials Chemistry B, 5(32), pp.6433–6442.

Self-Assembly

Shrivastava, A., Sana, B. and Lim, S., 2017. Humic acid-encapsulated ferritin nanoparticles for targeted therapy. Journal of Biomedical Materials Research Part A, 105(5), pp.1432–1441.

Health & Medicine

Karuppannan, S.K., Kumar, K.S., Pasula, R.R., Lim, S. and Nijhuis, C.A., 2017. Charge transport across ferritin biomolecular junctions. Advanced Functional Materials, 27(42), p.1702446.

Electronics

2016

Sun, R., Sana, B. and Lim, S., 2016. Structural plasticity of protein cages in response to chemical modifications. Biomacromolecules, 17(6), pp.2111–2119.

Self-Assembly

Krishnan, S., Sana, B. and Lim, S., 2016. Engineered ferritin nanocages as a versatile platform for drug delivery. Journal of Controlled Release, 235, pp.122–131.

Health & Medicine

2015

Sana, B., Sun, R. and Lim, S., 2015. Tailoring the assembly properties of protein nanocages via genetic engineering. Journal of Materials Chemistry B, 3(24), pp.4811–4818.

Self-Assembly

Bhaskar, S. and Lim, S., 2015. Evaluation of cellular interactions of functionalized protein nanocages. Journal of Biomedical Materials Research Part A, 103(4), pp.1342–1351.

Health & Medicine

2014 and earlier

Sun, R. and Lim, S., 2014. Assembling protein cages into complex macrostructural networks. Applied Nanoscience, 4(7), pp.811–819.

Self-Assembly

Sana, B. and Lim, S., 2014. Humic acid-conjugated ferritin nanoparticles for target-specific molecular imaging. Journal of Biomedical Materials Research Part A, 102(3), pp.723–731.

Health & Medicine

Bhaskar, S. and Lim, S., 2014. Engineering protein nanocages as a container system for drug delivery application. Biomaterials, 35(1), pp.444–454.

Health & Medicine

Lim, S., 2013. Fascinating molecular containers: architectures and functionalizations of protein cages. Biotechnology and Bioprocess Engineering, 18(1), pp.1–11.

Self-Assembly

Lim, S., 2012. The emergence of protein cages in bionanotechnology. Journal of Biotechnology & Biomaterial, 2(3), p.e107.

Self-Assembly

Zhao, Q., Lim, S. and Wang, S.-W., 2011. A design methodology to tune disassembly properties in a caged protein platform. Biotechnology and Bioengineering, 108(8), pp.1741–1751.

Self-Assembly

Lim, S., 2010. Functionalizing the inside of protein cages for medical applications. Biointerphases, 5(3), pp.FA48–FA52.

Health & Medicine

Dalmau, M., Lim, S. and Wang, S.-W., 2009. pH-triggered disassembly in a caged protein complex. Biomacromolecules, 10(12), pp.3199–3206.

Self-Assembly

Dalmau, M., Lim, S. and Wang, S.-W., 2009. Design of a pH-dependent molecular switch in a caged protein platform. Nano Letters, 9(1), pp.160–166.

Self-Assembly

Notable Reviews

Uchida M, Young M, Douglas T (2007) Biological Containers: Protein Cages as Multifunctional Nanoplatforms - Uchida - 2007 - Advanced Materials - Wiley Online Library 

Bhaskar SM, Lim S (2017) Engineering protein nanocages as carriers for biomedical applications | NPG Asia Materials 

Heedle JG, Chakraborti S, Iwasaki K (2017) Natural and artificial protein cages: design, structure and therapeutic applications - ScienceDirect

Aumiller WM, Uchida M, Douglas T (2018) Protein cage assembly across multiple length scales - Chemical Society Reviews (RSC Publishing)

Neek M, Kim TI, Wang S-W (2019) Protein-based nanoparticles in cancer vaccine development - ScienceDirect

Korpi A, Kostiainen M, et al. (2019) Protein-based nanoparticles in cancer vaccine development - ScienceDirect

Steinmetz N, Lim S, Sainsbury F (2020) Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics - Biomaterials Science (RSC Publishing) 

Berckman EA, Chen W, et al. (2020) Biological Assembly of Modular Protein Building Blocks as Sensing, Delivery, and Therapeutic Agents | Annual Reviews 

Kaku T, Lim S (2021) Protein nanoparticles in molecular, cellular, and tissue imaging - Kaku - 2021 - WIREs Nanomedicine and Nanobiotechnology - Wiley Online Library

Lim S, Salentinig S (2021) Protein nanocage-stabilized Pickering emulsions - ScienceDirect

Edwardson TGW, Hilvert D, et al. (2022) Protein Cages: From Fundamentals to Advanced Applications | Chemical Reviews 

Mallik BB, Khmelinskaia A, et al. (2023) De Novo Design of Polyhedral Protein Assemblies: Before and After the AI Revolution - Mallik - 2023 - ChemBioChem - Wiley Online Library

Books